Reactivity of Apolipoprotein E4 and Amyloid β Peptide
نویسندگان
چکیده
منابع مشابه
Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide.
Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder causing dementia. Massive deposition of amyloid β peptide (Aβ) as senile plaques in the brain is the pathological hallmark of AD, but oligomeric, soluble forms of Aβ have been implicated as the synaptotoxic component. The apolipoprotein E ε 4 (apoE ε4) allele is known to be a genetic risk factor for developing AD...
متن کاملNeurobiology of Disease Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid Peptide
Tadafumi Hashimoto,1 Alberto Serrano-Pozo,1 Yukiko Hori,1 Kenneth W. Adams,1 Shuko Takeda,1 Adrian Olaf Banerji,1 Akinori Mitani,1 Daniel Joyner,1 Diana H. Thyssen,1 Brian J. Bacskai,1 Matthew P. Frosch,1 Tara L. Spires-Jones,1 Mary Beth Finn,2 David M. Holtzman,2 and Bradley T. Hyman1 1Department of Neurology, Alzheimer’s Disease Research Unit, Massachusetts General Hospital, Charlestown, Mass...
متن کاملPeripheral Inflammation, Apolipoprotein E4, and Amyloid-β Interact to Induce Cognitive and Cerebrovascular Dysfunction
Cerebrovascular dysfunction is rapidly reemerging as a major process of Alzheimer's disease (AD). It is, therefore, crucial to delineate the roles of AD risk factors in cerebrovascular dysfunction. While apolipoprotein E4 ( APOE4), Amyloid-β (Aβ), and peripheral inflammation independently induce cerebrovascular damage, their collective effects remain to be elucidated. The goal of this study was...
متن کاملAssociation between Amylin and Amyloid-β Peptides in Plasma in the Context of Apolipoprotein E4 Allele
Amylin, a pancreatic peptide that readily crosses the blood brain barrier (BBB), and amyloid-beta peptide (Aβ), the main component of amyloid plaques and a major component of Alzheimer's disease (AD) pathology in the brain, share several features. These include having similar β-sheet secondary structures, binding to the same receptor, and being degraded by the same protease. Thus, amylin may be...
متن کاملApolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.
We assessed the isoform-specific effects of apolipoprotein (apo) E on the response of Neuro-2a cells to the amyloid beta peptide (Abeta1-42). As determined by the intracellular staining pattern and the release of beta-hexosaminidase into the cytosol, apoE4-transfected cells treated with aggregated Abeta1-42 showed a greater tendency toward lysosomal leakage than neo- or apoE3-transfected cells....
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m506646200